Research Program
Vascular Biology & Regeneration
Decoding the endothelium in health, disease, and regeneration.
Overview
Our scientific focus
The vascular endothelium is an active signaling interface that senses mechanical, inflammatory, metabolic, and environmental cues. We study how endothelial dysfunction and plasticity contribute to cardiovascular disease and how vascular function can be restored.
Endothelial dysfunctionIntegrated human models and mechanistic studies.
Endothelial plasticity & EndoMTIntegrated human models and mechanistic studies.
Vascular regenerationIntegrated human models and mechanistic studies.
Our Approach
From human disease to mechanism.
Our studies integrate patient-derived vascular specimens, iPSC-derived endothelial cells, functional vascular phenotyping, genome engineering, and multi-omic profiling to identify regulatory programs controlling vascular injury and repair.
Explore More
Connecting this program across the Sayed Lab.
See the platforms, publications, and people that make this research possible.