Research Program
Functional Cardiovascular Genomics
Moving from genetic association to causal cardiovascular biology.
Overview
Our scientific focus
Human genetics identifies disease-associated variants, but association alone does not establish mechanism. We use functional genomics and genome engineering to determine how genetic variation alters cardiovascular cell states and function.
CRISPR & precision editingIntegrated human models and mechanistic studies.
Variants of uncertain significanceIntegrated human models and mechanistic studies.
Regulatory genomicsIntegrated human models and mechanistic studies.
Our Approach
From human disease to mechanism.
We introduce or correct candidate variants in controlled iPSC backgrounds, differentiate engineered cells into cardiovascular lineages, and integrate functional phenotyping with transcriptomic and epigenomic profiling. Multicellular models allow promising variants to be evaluated at tissue level.
Explore More
Connecting this program across the Sayed Lab.
See the platforms, publications, and people that make this research possible.