Research Program
Environmental Cardiovascular Disease
Modeling how environmental exposures shape cardiovascular health.
Overview
Our scientific focus
Cardiovascular disease reflects interactions between genetic susceptibility and environmental exposures accumulated throughout life. We develop human experimental systems to investigate how environmental stressors alter vascular and cardiac biology.
Environmental exposuresIntegrated human models and mechanistic studies.
Gene–environment interactionsIntegrated human models and mechanistic studies.
Human exposure modelsIntegrated human models and mechanistic studies.
Our Approach
From human disease to mechanism.
Using iPSC-derived cardiovascular cells and multicellular models, we study endothelial injury, inflammation, oxidative stress, remodeling, and persistent molecular responses to environmental exposures. These studies connect exposure biology with mechanistic cardiovascular phenotypes.
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Connecting this program across the Sayed Lab.
See the platforms, publications, and people that make this research possible.