Research Program
Cardiomyopathy & Heart Failure
Understanding the failing heart as a multicellular disease.
Overview
Our scientific focus
Cardiomyopathy has traditionally been viewed primarily as a disorder of cardiomyocytes. Our work investigates a broader model in which endothelial cells, cardiomyocytes, fibroblasts, immune cells, and the surrounding microenvironment interact to determine disease progression and recovery.
Endothelial–cardiomyocyte crosstalkIntegrated human models and mechanistic studies.
Genetic cardiomyopathyIntegrated human models and mechanistic studies.
Cardiac remodeling & fibrosisIntegrated human models and mechanistic studies.
Our Approach
From human disease to mechanism.
We combine patient-derived and genome-engineered iPSCs with multicellular cardiac organoids, engineered tissues, single-cell and spatial profiling, and in vivo models. A major focus is defining vascular–myocardial signaling programs in LMNA cardiomyopathy and identifying pathways that can be therapeutically redirected.
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Connecting this program across the Sayed Lab.
See the platforms, publications, and people that make this research possible.